The video "Naruto: 10 Saddest Deaths, Ranked" discusses the most heartbreaking deaths in the Naruto anime series. The video explains that no character, whether a hero or villain, is safe from a sudden and tragic death in Naruto, making the deaths even more impactful. With 720 episodes between Naruto and Naruto: Shippuden, these deaths hit harder because the characters had grown on viewers and made them like them. The video then goes on to rank and describe the ten saddest deaths in the series, including Neji, Granny Chiyo, Hiruzen Sarutobi (Third Hokage), Obito, Asuma, Itachi, and Kakashi. The video also provides background information on each character and the circumstances surrounding their death.