8 MLB Picks & Predictions Today 9/27/25 | MLB Picks Today 9/27/25 | Best MLB Picks ► Baltimore Orioles vs New York Yankees Prediction. The New York Yankees aim to extend a six-game winning streak Saturday afternoon at home against the Baltimore Orioles. New York sits at 92-68, tied with Toronto atop the AL East standings. They earned an 8-4 victory over Baltimore in Friday's series opener. ► St. Louis Cardinals vs Chicago Cubs Prediction. The Chicago Cubs aim to secure home-field advantage for the Wild Card round Saturday afternoon at home against the St. Louis Cardinals. Chicago sits at 90-70, holding the top NL Wild Card spot . They earned a 12-1 victory over St. Louis in Friday's series opener . ► Tampa Bay Rays vs Toronto Blue Jays Prediction. The Tampa Bay Rays aim to avoid a third consecutive loss Saturday afternoon on the road against the Toronto Blue Jays. Tampa Bay sits at 77-83, fourth in the AL East and eliminated from playoff contention . ► Colorado Rockies vs San Francisco Giants Prediction. The Colorado Rockies aim to snap a four-game losing streak Saturday afternoon on the road against the San Francisco Giants. Colorado sits at 43-117, with the worst record in Major League Baseball . They suffered a 6-3 loss to the Giants on Friday . ► Chicago White Sox vs Washington Nationals Prediction. The Chicago White Sox aim to build on a dramatic victory Saturday afternoon on the road against the Washington Nationals. Chicago sits at 59-101, with the worst record in the American League . They earned a 10-9 victory over Washington on Friday, snapping an extended losing streak . ► New York Mets vs Miami Marlins Prediction. The New York Mets aim to rebound from a series-opening loss Saturday afternoon on the road against the Miami Marlins. New York sits at 82-78, holding a one-game lead for the final National League Wild Card spot . ► Detroit Tigers vs Boston Red Sox Prediction. The Detroit Tigers aim to avoid a historic collapse and keep their playoff hopes alive Saturday afternoon on the road against the Boston Red Sox. Detroit sits at 86-74, tied with Cleveland for the AL Central lead but without control of the tiebreaker after a 4-3 loss to Boston on Friday . ► Minnesota Twins vs Philadelphia Phillies Prediction. The Minnesota Twins aim to avoid a second consecutive loss Saturday night on the road against the Philadelphia Phillies. Minnesota sits at 69-91, fourth in the AL Central . They suffered a 3-1 loss to the Phillies on Friday . ► mlb picks today,mlb predictions today,baseball picks today,mlb picks,mlb predictions,mlb bets today,mlb prediction today,baseball predictions today,mlb betting picks today,mlb bets,pickdawgz mlb ,best mlb bets today,mlb bets tonight,mlb betting,mlb predictions for today,pickdawgz mlb picks today,sports bets today,best mlb picks today,free mlb picks today,mlb today,mlb dfs,mlb dfs today,baseball predictions today,baseball predictions,mlb picks 9/27,mlb 9/27, ► #mlbpickspreviews #mlbpredictionstoday #freemlbpicks #mlblb ► Music track: Mood by Sunova Source: https://freetouse.com/music No Copyright Music (Free Download)